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Everything about Statistical Significance totally explained

In statistics, a result is called statistically significant if it's unlikely to have occurred by chance. "A statistically significant difference" simply means there's statistical evidence that there's a difference; it doesn't mean the difference is necessarily large, important, or significant in the common meaning of the word. The significance level of a test is a traditional frequentist statistical hypothesis testing concept. In simple cases, it's defined as the probability of making a decision to reject the null hypothesis when the null hypothesis is actually true (a decision known as a Type I error, or "false positive determination"). The decision is often made using the p-value: if the p-value is less than the significance level, then the null hypothesis is rejected. The smaller the p-value, the more significant the result is said to be.
   In more complicated, but practically important cases, the significance level of a test is a probability such that the probablility of making a decision to reject the null hypothesis when the null hypothesis is actually true is no more than the stated probability. This allows for those applications where the probability of deciding to reject may be much smaller than the significance level for some sets of assumptions encompassed within the null hypothesis.

Use in practice

The significance level is usually represented by the Greek symbol, α (alpha). Popular levels of significance are 5%, 1% and 0.1%. If a test of significance gives a p-value lower than the α-level, the null hypothesis is rejected. Such results are informally referred to as 'statistically significant'. For example, if someone argues that "there's only one chance in a thousand this could have happened by coincidence," a 0.1% level of statistical significance is being implied. The lower the significance level, the stronger the evidence.
   In some situations it's convenient to express the statistical significance as 1 − α. In general, when interpreting a stated significance, one must be careful to note what, precisely, is being tested statistically.
   Different α-levels have different advantages and disadvantages. Smaller α-levels give greater confidence in the determination of significance, but run greater risks of failing to reject a false null hypothesis (a Type II error, or "false negative determination"), and so have less statistical power. The selection of an α-level inevitably involves a compromise between significance and power, and consequently between the Type I error and the Type II error.
   In some fields, for example nuclear and particle physics, it's common to express statistical significance in units of "σ" (sigma), the standard deviation of a Gaussian distribution. A statistical significance of "nsigma" can be converted into a value of α via use of the error function:
» alpha = 1 - operatorname.

For clarity, the above formula is presented in tabular form below. Dependence of confidence with noise, signal and sample size (tabular form)
Parameter Parameter increases Parameter decreases
Noise Confidence decreases Confidence increases
Signal Confidence increases Confidence decreases
Sample size Confidence increases Confidence decreases
In words, the dependence of confidence is high if the noise is low and/or the sample size is large and/or the effect size (signal) is large. The confidence of a result (and its associated confidence interval) is not dependent on effect size alone. If the sample size is large and the noise is low a small effect size can be measured with great confidence. Whether a small effect size is considered important is dependent on the context of the events compared.
   In medicine, small effect sizes (reflected by small increases of risk) are often considered clinically relevant and are frequently used to guide treatment decisions (if there's great confidence in them). Whether a given treatment is considered a worthy endeavour is dependent on the risks, benefits and costs.

Further Information

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